The Protective Effect of Some Antioxidants on Aluminium Accumulation in Sexual Organs and Accessory Glands of Male Rats

The aim of the study was to evaluate the protective status of an antioxidant combination (melatonin and Sempervivum tectorum extract) on aluminium accumulation in genital organs of male rats. The 12 weeks study was carried out on 35 Wistar male rats divided in five groups: C – control, receiving distillated water; E1 – aluminium sulphate 0.1 mg/L; E2 – melatonin 10 mg/kg b.w. in drinking water; E3 – 6% aqueous extract of Sempervivum tectorum; E4 – combination, melatonin and plant extract. The study pointed out the significant (p<0.001) accumulation of aluminium in testis and accessory glands comparative to control. The aluminium level was significantly (p<0.05) reduced in groups exposed to melatonin and S. tectorum extract compared to aluminium exposed group, remaining still significantly (p<0.05) higher than in control. The combination of used antioxidants (E4) was proven more efficient in protection against aluminium accumulation, especially in testis.